Cruella is the head of the London fashion house called House of De Vil. Anita Dearly is one of Cruella's employees and hinted to be her best fashion designer. Cruella first took interest in the Dalmatian puppies when Anita drew spots on one of the designs. Cruella has another henchman, named Mr. Skinner, a taxidermist. She hires him to kill and skin the puppies for the designs. Cruella sent Horace and Jasper Badun to capture the puppies, but they fail thanks to the intervention of the farm animals. Cruella herself then went after the puppies after her henchmen were defeated, and located the puppies to the farm. She tried to kill them but fell victim to the farm animals, who managed to trick and outwit her and defeated her by knocking her into mud. Cruella was later arrested for her crimes along with her henchmen.
Cruella has seemingly been released of her obsession of furs and now loves puppies and has decided to get rid of her fashion house because the clothes are made out of fur. While visiting Chloe Simon, one of the puppies nearly falls out the window and while Chloe and the other puppies try to rescue her, Cruella hears the chimes of Big Ben and she reverts back to her original obsession with spots, seeing black spots everywhere and she now wants 102 Dalmatian puppies for her designs. She enlists the help of another fashion designer named Jean-Pierre Le Pelt and an unwilling butler named Alonzo. She frames the owner of the animal shelter Kevin Shepherd for kidnapping the puppies and he is arrested. He escapes from jail and tries to help Chloe rescue the puppies, but they are trapped by Cruella. The puppies escape and Cruella tries to capture them, and at the same time Alonzo redeems himself by defeating Jean-Pierre Le Pelt and freeing Chloe and Kevin while Cruella is defeated by getting baked in a cake. The police come and arrest her and Le Pelt.