The first antagonist of a movie, T.V. show, video game, and book, or the antagonist you need to worry about most. Main antagonists usually appear in the climax or beginning.
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Heinz Doofenshmirtz
All items (434)
A
B
- Beatrice Stanhope
- Beauty Smith
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- Big Bad
- Bizarrah
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- Bread Baron
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- Buldeo
- Buster
C
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- Candace Adams
- Captain Bill Fawcett
- Captain Finn
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- Captain Salazar
- Captain Wraith
- Cardinal Richelieu
- Carla Santini
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- Cattlemen
- Celia Rodriguez
- Chacha
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- Chad Charming
- Chainsaw
- Chancellor Goodwin
- Chancellor Trample
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- Charlie Olympus
- Chessbot 5000
- Chick Hicks
- Christmas Star Bird
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- CLU 2.0
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- Cob
- Colonel Pierson
- Commander Buck Burpelson
- Commander Heist
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- Coney Island Freaks
- Connie
- Cool Hands Luke
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- Covington
- Cranky
- Cruella De Vil
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D
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- Dan and Iggy
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- Darci
- Daring Dan Dawson
- Darth Vader
- Dave Clark
- David Nix
- Debbie Dazzle
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- Despoina
- Ding and Oopo
- Doctor Facilier
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- Doofenshmirtz (1914)
- Doris
- Doug Slackwell
- Douglas Benson
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- Dr. Blakk
- Dr. Diente
- Dr. Elliot Coleye
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- Dr. Gao
- Dr. Homer
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- Dr. Nocturno
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- Dr. Paul Bunion
- Dr. Phillip Wellington
- Dr. Pogo
- Dr. Screwball Jones
- Dr. Tobar
- Duke Igthorn
E
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- Eddie Taffet
- Egghead (Lucky Fred)
- Eighth Brother
- Electro (The Amazing Spider-Man 2)
- Elektra
- Elephant Hunters
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- Emile Crocker
- Emperor Palpatine
- Erik Hellstrom
- Ernesto de la Cruz
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- Estelle Dabney
- Evelyn Deavor
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F
- Fabrica
- Felix Nash
- Fifth Brother
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- Foreman Takeda
- Frakes
- Frank Stillwell
- Fritter O'Way
G
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- Gadfly Garnett
- Gary Fulcher
- Gaspar Le'Gecko
- General Grievous
- General Hux
- General Tesler
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- Ghost Host
- Ghost of Northwest Manor
- Giant Buford
- Gilbert Sipes
- Giles Winslow Jr.
- Glacia the Ice Witch
- Gloom
- Gnocci
- Goat Man
- Gordie Gibble
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- Grace Goodwin
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- Green Goblin (Spider-Man)
- Gregorio Casal
- Grotta
- Growler
H
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- Hans Reinhardt
- Harley Keiner
- Harold
- Harry Bundage
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- Heinz Doofenshmirtz
- Hela
- Helga (Proud Family)
- Henry Villanova
- HEX
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- Hnup Wan
- Hopper
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- Hottie
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I
J
- J. J. Wagstaff
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- Jackson Storm
- Jacques Lebeau
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- Jake and Sam
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- Jane Keller
- Janice Avery
- Janja
- Jean George III
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- Jennifer Stone
- Jenny (Beverly Hills Chihuahua)
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- Jerry Driscoll
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- Jessica Dintroff
- Joe Muffaw
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- John Ricketts
- John Slade
- Johnny Worthington III
- Judge Higgins
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